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Putting black pepper on your food may be one of the easiest, most economical ways to boost your overall well-being. Piperine, the main alkaloid from black pepper has been shown to substantially increase the bioavailability of the nutrients in foods and supplements. Piperine is a pungent compound found in the fruit of plants in the Piperaceae family, the most famous member of which is Piper nigrum, black pepper. Black pepper has a long history of use in Ayurvedic medicine as a restorative food. Piperine may help nutrients reach, enter and remain within their target cells for longer periods of time. As a result, a somewhat effective therapeutic substance may turn into a highly effective one by increasing its intracellular time.